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Hyaluronidase - Aftercare Guide

Immediately After Injection (First Few Hours)

Expected Immediate Reactions

  • Mild discomfort at injection sites
  • Small needle marks visible
  • Possible minimal swelling or redness
  • Very brief stinging sensation (fades quickly)
  • No systemic effects immediately

Immediate Care

  • Ice pack application optional for comfort
  • Avoid touching or massaging injection sites
  • Continue normal activity
  • Avoid hot water or heat for first few hours
  • Keep sites clean and dry

After care

First Week: Active Filler Dissolution

Filler Dissolution Timeline

  • Approximately 50% of filler dissolves within 1-2 days
  • Remaining filler dissolves progressively over 7 days
  • Gradual absorption through natural body processes
  • Timeline may vary by individual and filler type
  • Process continues naturally for full week

Physical Changes to Expect

  • Mild to moderate swelling possible
    • Swelling from injection trauma and enzyme activity
    • Peaks usually at 24-48 hours
    • Can last 3-7 days depending on extent
    • Varies significantly by individual

Bruising Management

  • Bruising common with hyaluronidase injections
    • Peaks at 24-48 hours
    • May appear more significant than initial swelling
    • Usually fades within 5-7 days
    • Arnica supplements may help
    • Ice packs help reduce swelling

Activity Restrictions (First Week)

  • Avoid strenuous exercise for 24-48 hours
  • Avoid heat exposure (saunas, hot baths) for 24-48 hours
  • Avoid alcohol for 24-48 hours
  • Avoid smoking for at least 24-48 hours
  • Avoid massage or pressure on treated areas
  • Avoid aggressive facial treatments
  • Minimize facial expressions in treated area
  • Avoid sleeping on treated areas

Skincare During First Week

  • Gentle cleansing; avoid vigorous rubbing
  • Avoid makeup on injection sites for 24 hours
  • Avoid active ingredients (retinol, AHA, BHA) for 1 week
  • Use fragrance-free, gentle products only
  • Avoid sun exposure; use SPF 30+ if outdoors
  • Keep treated areas clean and dry

Injection Site Care

  • Small needle marks resolve within days
  • No specific care usually needed
  • Avoid touching or manipulating
  • Keep clean; normal hygiene sufficient
  • No special bandages or coverings needed

Filler Dissolution Observations

  • Visible softening of treated area over days
  • Firmness gradually diminishing
  • Previously enlarged area shrinking progressively
  • Gradual improvement in appearance
  • Full effect of dissolution visible by day 7

Other Possible Effects

  • Mild headache possible (rare)
  • Temporary heaviness in treated area
  • Temporary numbness (very rare, temporary)
  • Mild malaise or flu-like feeling (very rare)
  • All usually temporary and very mild

Sleep and Rest

  • Normal sleep generally acceptable after first night
  • Sleep on back if possible first night
  • Otherwise normal sleep resumable
  • Adequate rest supports healing

Weeks 2-4: Completion of Dissolution

Observable Changes

  • Filler completely or nearly completely dissolved by end of week 1
  • Swelling significantly improved by week 2
  • Bruising faded by end of week 2-3
  • Area appearing much softer and more natural
  • Previously problematic appearance improved
  • Results of dissolution fully apparent by week 2

Area Assessment

  • Area now appears more normal and natural
  • Softness and lack of firmness obvious
  • Over-correction from previous filler corrected
  • Asymmetry (if present before) now corrected
  • Overall improvement in appearance evident

Lifestyle Resumption

  • Normal exercise resumable after 48 hours (if swelling resolved)
  • Light activity acceptable before full healing
  • Heat exposure resumable by day 2-3
  • Alcohol consumption resumable
  • Smoking should ideally continue to be avoided
  • Normal social and professional activities resumable

Skincare Status

  • More aggressive skincare resumable after 1 week
  • Active ingredients resumable cautiously after week 1
  • Sun protection continues important
  • Gentle facial massage acceptable
  • Professional facials resumable after 1 week
  • Moisturizing treatments beneficial

Follow-up Considerations

  • Area fully assessed by end of week 2
  • Determine if additional dissolution needed
  • Evaluate results and patient satisfaction
  • Plan for any additional treatment if necessary
  • Contact clinic with concerns about results

Medication Restrictions

  • NSAIDs resumable if previously taken
  • Aspirin resumable if previously taken
  • Anti-inflammatory medications resumable
  • Specific restrictions from provider followed

Months 2-3: Final Results and Planning

Observable Results

  • Complete filler dissolution confirmed
  • Area appears entirely natural
  • Swelling completely resolved
  • Bruising completely faded
  • Any asymmetry fully corrected
  • Patient satisfaction typically achieved

Timeline Confirmation

  • Filler completely dissolved by end of week 1-2
  • Full improvement evident by week 3-4
  • Results stable and permanent by month 2
  • No regression of results expected
  • Area remains stable going forward

Lifestyle Fully Resumed

  • No restrictions on any activities
  • Normal exercise unrestricted
  • Heat exposure unrestricted
  • Alcohol and other substances unrestricted
  • Skincare completely normal
  • Complete return to normal

Planning for Future

  • Consider alternatives if filler dissolution was necessary
  • Discuss next steps with provider
  • Plan for potential new treatments if desired
  • Consider different filler types or approaches
  • Build plan with provider for long-term aesthetic goals

When to Consider Additional Treatment

  • If partial dissolution needed, additional doses possible
  • If full dissolution confirmed, complete and permanent
  • Future filler treatments can be reconsidered
  • Timing for new treatments discussed with provider
  • Different approach or filler type considered

Important Information About Hyaluronidase

Purpose and Function

  • Enzyme that breaks down hyaluronic acid-based fillers
  • Used for filler dissolution or correction
  • Safe and effective for filler removal
  • Can be precisely targeted
  • Reversible correction possible

Safety Considerations

  • FDA-approved for filler dissolution
  • Requires qualified healthcare provider
  • Medical assessment necessary
  • Complete medical history important
  • Allergies to enzyme must be assessed
  • Previous reactions to hyaluronidase must be disclosed

Potential Side Effects

  • Swelling common but temporary
  • Bruising common but temporary
  • Redness at injection sites
  • Tenderness in treated area
  • All typically resolve within 1-2 weeks
  • Serious side effects very rare

Serious Complications (Very Rare)

  • Severe allergic reaction (extremely rare)
  • Severe swelling (rare)
  • Infection at injection site (rare)
  • Other serious complications extremely rare
  • Any severe symptoms warrant medical attention

Restrictions

  • Cannot use if allergic to hyaluronidase or components
  • Cannot use if active infection present
  • Caution with blood thinners
  • Pregnancy typically contraindicates treatment
  • Complete medical history necessary

Dietary and Lifestyle Recommendations

General Health During Recovery

  • Maintain healthy diet for overall wellness
  • Stay well-hydrated (important for healing)
  • Adequate sleep important (supports healing)
  • Manage stress effectively
  • Regular gentle exercise beneficial

Sun Protection

  • SPF 30+ sunscreen daily
  • Sun protection important for treated area
  • UV exposure can affect healing
  • Reapply every 2 hours if outdoors
  • Avoid peak sun hours if possible

Skincare During Healing

  • Gentle, non-irritating products only
  • Moisturize regularly
  • Avoid harsh products
  • Professional skincare treatments supportive after healing

Medical Supervision

  • Choose qualified, experienced provider
  • Board-certified preferred
  • Clear communication about goals
  • Follow-up assessment important
  • Contact provider with any concerns

When to Contact Your Provider

Contact immediately if experiencing:

  • Severe swelling that worsens progressively
  • Signs of infection (increasing redness, warmth, pus)
  • Severe allergic reaction symptoms
  • Difficulty breathing or chest symptoms
  • Severe pain
  • Any severe or concerning symptoms

Contact for routine follow-up:

  • Week 1 assessment of dissolution progress
  • Week 2-3 final assessment
  • Discuss results and satisfaction
  • Plan for any additional treatment if needed
  • Address any concerns about appearance
  • Follow-up care and guidance

Dermatology

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