How It Works

Rejuran Healer works through a sophisticated biological process:

Stage One: Activation of Skin Healing Response

When PDRN is injected into the dermis layer, it activates fibroblasts and other skin cells by mimicking natural DNA signals. This triggers the body’s innate healing and regeneration mechanisms. The PDRN essentially tells your skin cells “we need to repair and regenerate,” activating pathways that would normally be dormant in aging skin.

Stage Two: Increased Blood Flow and Nutrient Delivery

The activated healing response increases blood circulation in the treated areas. This improved blood flow delivers more oxygen and nutrients to skin cells, supporting their function and regeneration. Better circulation also helps remove waste products and toxins, improving overall skin health.

Stage Three: Collagen and Elastin Production

As fibroblasts become more active, they increase production of collagen, elastin, and other structural proteins that give skin its firmness and elasticity. This natural production of these proteins gradually improves skin thickness, elasticity, and resilience. Unlike temporary fillers, these improvements are based on your skin actually becoming healthier and stronger.

Stage Four: Long-Term Skin Quality Improvement

Over weeks and months, the cumulative effects of increased collagen and elastin production, improved circulation, and enhanced cell function result in visibly improved skin quality. The skin becomes smoother, more radiant, and more resilient to further aging.

Main Effects of Rejuran Healer

Although results vary from person to person, you can generally expect the following effects:

Immediate Effects: Within 3-5 days after injection, you will notice the skin appears more hydrated and glowing. The skin feels softer and smoother to the touch. Skin texture improves noticeably.

Progressive Effects: From one to four weeks after treatment, skin becomes increasingly radiant and elastic. Fine lines become less noticeable. The skin’s overall quality and appearance continue to improve. These effects continue to develop for up to three months.

Main Improvements: Improved skin texture, enhanced skin radiance and glow, increased skin elasticity and firmness, reduced fine lines and wrinkles, improved skin hydration, reduced skin sensitivity, strengthened skin barrier, smaller pores, improved skin tone evenness, and overall younger-looking skin.

Key Differences From Other Treatments

Understanding what makes Rejuran Healer unique helps you appreciate its benefits:

Rejuran Healer vs. Juvelook: Both are injection treatments that stimulate collagen, but they work differently. Juvelook uses PLA and PDLLA particles that physically remain in the skin longer, while Rejuran Healer uses DNA extract that is metabolized and disappears, leaving only improved skin behind. Rejuran Healer is better for skin quality improvement, while Juvelook is better for significant volume restoration.

Rejuran Healer vs. Traditional Fillers: Traditional fillers like hyaluronic acid simply fill space temporarily. Rejuran Healer actually improves the skin’s biological function and quality, creating longer-lasting and more natural results.

Rejuran Healer vs. Ultherapy or Inmode: While Ultherapy and Inmode use energy-based technologies to stimulate collagen, Rejuran Healer uses biological signals to activate skin regeneration. They work through different mechanisms and can complement each other well.

Rejuran Healer vs. Laser or Chemical Peels: Peeling treatments remove damaged outer layers, while Rejuran Healer builds up skin health from within. Rejuran Healer is gentler and suitable for sensitive skin, while peels provide more dramatic surface improvement.

Who Should Get This Treatment?

Rejuran Healer is especially recommended for the following people:

People with dry or dehydrated skin: The treatment significantly improves skin hydration and is especially effective for chronically dry skin.

People with sensitive skin: Unlike harsh treatments, Rejuran Healer is very gentle and actually strengthens the skin barrier, making it excellent for sensitive skin.

People with thin or delicate skin: If your skin is thin or feels fragile, Rejuran Healer strengthens and thickens the skin naturally.

People with dull or tired-looking skin: The treatment restores radiance and a healthy glow to dull, tired skin.

People with fine lines and minor wrinkles: While it does not eliminate deep wrinkles like more aggressive treatments, it is excellent for improving overall skin texture and reducing fine lines.

People wanting natural skin improvement: If you want to improve skin quality without dramatic changes or looking artificially treated, Rejuran Healer is ideal.

People with compromised skin barrier: Those with rosacea, sensitivity, or irritation benefit from Rejuran Healer’s barrier-strengthening effects.

People over 25-30: While appropriate for younger people, Rejuran Healer is especially popular among people in their late 20s and beyond seeking preventative or corrective skin care.

How Is the Procedure Done?

The procedure is relatively quick and straightforward:

Before Treatment: Your face is cleansed thoroughly and photos are taken for comparison. The doctor assesses your skin condition and determines which areas need treatment. Rejuran Healer is typically applied to the face, neck, and décolletage area, though it can be used anywhere on the body. A numbing cream is applied to minimize discomfort.

During Treatment: The doctor injects Rejuran Healer using very fine needles into the dermis layer of the skin. The injections are placed in a pattern across the treatment area to ensure even distribution. You will feel small pinpricks as the injections are given, but the sensation is usually mild. The doctor may inject multiple times across the same area to ensure proper saturation of the product. The procedure typically takes 15-30 minutes depending on the areas treated.

Injection Technique: The doctor uses a specific injection technique to place the product at the correct depth in the dermis layer. Proper placement is important for optimal results, so choosing an experienced doctor is crucial.

After Injection: The treated area may appear slightly red or swollen immediately after injections. This typically subsides quickly. Some doctors apply a calming mask or serum to soothe the skin.

Is There Pain?

Rejuran Healer involves injections, so you will feel some sensation, but the experience is generally manageable:

Pain Level: Most people describe the sensation as mild pinpricks or slight pressure rather than sharp pain. The discomfort is usually very tolerable and minimal. Many people say the procedure is less painful than they expected.

Numbing Effectiveness: The numbing cream applied before treatment is usually sufficient to make the procedure comfortable for most people. You will feel the injections, but pain is minimal.

Variation by Area: Some facial areas are more sensitive than others. For example, the under-eye area may feel slightly more sensitive than the cheeks. Good doctors are experienced at minimizing discomfort in all areas.

Pain Management: If you have a low pain tolerance, you can request stronger numbing options, though most people find the procedure comfortable with standard numbing cream alone.

After Procedure: You should not experience significant pain after treatment. Some mild tenderness or sensitivity is normal and subsides within 24 hours.

How Many Sessions Do I Need?

To see optimal results from Rejuran Healer, usually 3-4 sessions are recommended. However, you will see some improvement even after one session.

Recommended Treatment Schedule: Sessions are typically spaced 2-4 weeks apart. This spacing allows the skin regeneration process to occur optimally between sessions. Some doctors recommend 2-week intervals for faster results.

1 Session: You will notice improved skin hydration and texture. Skin appears more radiant and glowing. Fine lines appear softer. These improvements are noticeable but subtle.

2 Sessions: More obvious improvements in skin elasticity and texture become apparent. The skin looks noticeably fresher and healthier. Fine lines are more significantly reduced.

3 Sessions: Maximum skin regeneration effects are typically achieved. Skin looks visibly younger, more elastic, and more radiant. This is the recommended minimum for optimal results.

4+ Sessions: Some people do additional sessions for even more dramatic improvements or for maintenance purposes.

Maintenance Sessions: After completing an initial course of 3-4 sessions, many people schedule 1-2 maintenance sessions per year to maintain the improved skin quality.

How Long Do the Results Last?

Rejuran Healer’s results generally last 3 to 6 months, with some people experiencing results lasting up to 9 months depending on individual factors.

This duration is actually quite good considering that the product itself is metabolized and disappears. The improvements last because your skin has actually become healthier and stronger with improved collagen and elastin production. The results are more durable than temporary fillers because they are based on actual improvements to your skin’s biological function.

The duration depends on factors including your age, metabolism, lifestyle, sun exposure, and overall health. People who maintain good skincare, use sunscreen, and have healthy lifestyles often experience longer-lasting results.

To maintain long-term improvements, many people schedule maintenance sessions 1-2 times per year, or repeat a full course of 3-4 sessions annually.

How Much Does It Cost?

The cost of Rejuran Healer varies depending on the clinic, the amount of product used, and the areas treated. Generally, one session costs 200,000 to 400,000 won, depending on the clinic and treatment scope.

For a basic course of 3-4 sessions, the total cost is typically 600,000 to 1,600,000 won. Some clinics offer package deals if you purchase multiple sessions upfront, which can provide slight savings.

It is important to choose a clinic with experienced doctors and authentic Rejuran Healer product, as counterfeit products exist in some markets. Cheap treatments may indicate inferior or fake products, so choose based on reputation and doctor experience rather than price alone.

What Is Downtime?

One of Rejuran Healer’s advantages is that it has minimal downtime, though slightly more than non-invasive treatments:

Immediate Effects: Redness and slight swelling at injection sites are common immediately after treatment. These typically fade within 24-48 hours.

Mild Bruising: Some people may experience light bruising at injection sites, especially if they have sensitive skin or are prone to bruising. This usually fades within 3-5 days.

Daily Activities: You can resume normal daily activities immediately after treatment. Most people go back to work or social activities the same day.

Makeup: You can apply makeup the next day if there is minimal bruising. Some people prefer to wait 24 hours to let the skin fully settle.

Exercise and Activities: You should avoid strenuous exercise, saunas, steam rooms, and hot water for 24-48 hours after treatment to minimize swelling and bruising. After this period, you can resume all normal activities.

Skin Sensitivity: The treated area may be slightly more sensitive for 24-48 hours, so avoid harsh skincare products during this time.

Are There Any Side Effects?

Rejuran Healer is considered very safe, but like all injection procedures, there are potential side effects:

Common Side Effects: Redness, swelling, bruising, and temporary tenderness at injection sites are the most common. These typically resolve within 24-72 hours without treatment.

Rare Side Effects: In rare cases, temporary itching, slight sensitivity, or mild irritation can occur. These typically resolve within a few days.

Very Rare Side Effects: Allergic reactions are extremely rare since PDRN is a naturally derived ingredient. Infection is also rare when the procedure is performed under proper sterile conditions.

Individual Variation: Some people experience minimal side effects while others may experience more noticeable bruising or swelling. This variation is normal and does not indicate a problem.

Side Effect Prevention: Choosing a clinic with experienced injectors using proper sterile technique greatly reduces the risk of complications. Proper aftercare also helps minimize side effects.

Post-Treatment Care Tips

Following proper aftercare helps maximize Rejuran Healer results and minimize side effects:

Avoid Heat for 48 Hours: Stay away from saunas, steam rooms, hot baths, and intense exercise for at least 2 days after treatment. Heat increases blood flow and can increase swelling and bruising.

Avoid Alcohol: For the first 24-48 hours after treatment, avoid alcohol as it can increase bruising and swelling.

Avoid Blood Thinners: For the first 24-48 hours, avoid aspirin and similar blood-thinning medications, as these can increase bruising. Consult your doctor if you take these medications regularly.

Use Ice: Applying ice packs for 10-15 minutes several times during the first 24 hours can help reduce swelling and bruising.

Keep the Area Clean: Wash gently with mild soap and keep the treated area clean to prevent infection.

Avoid Touching or Massaging: Do not massage or press on the treated areas for at least one week, as this can affect the distribution of the product.

Use Gentle Skincare: Use mild, non-irritating skincare products for the first week. Avoid harsh scrubs, strong chemical peels, and irritating ingredients.

Moisturize Well: Use a gentle, hydrating moisturizer to support skin healing. Rejuran Healer works best on well-hydrated skin.

Sun Protection: Apply SPF 30 or higher sunscreen daily. Sun exposure can interfere with skin regeneration. This is especially important for the first two weeks after treatment.

Stay Hydrated: Drink plenty of water to support skin healing and regeneration. Aim for at least eight glasses per day.

Sleep Well: Get adequate sleep to support your body’s natural regeneration processes.

Can I Combine Rejuran Healer With Other Treatments?

Rejuran Healer works excellently in combination with other treatments for enhanced results:

Rejuran Healer + Ulthera: Ulthera’s deep lifting combined with Rejuran Healer’s skin regeneration creates comprehensive anti-aging results. Ulthera provides structural lifting while Rejuran Healer improves overall skin quality.

Rejuran Healer + Inmode: This combination provides both skin quality improvement and lifting effects. Rejuran Healer strengthens the skin while Inmode tightens and refines it.

Rejuran Healer + Juvelook: Both treatments stimulate collagen and skin regeneration. When combined, they provide superior skin quality and volume restoration effects.

Rejuran Healer + Aqua Peel: Aqua Peel’s gentle cleansing before Rejuran Healer can prepare the skin and potentially enhance absorption of the PDRN product.

Rejuran Healer + Thermage: Both promote collagen regeneration through different mechanisms. Combined, they provide more comprehensive skin improvement and tightening.

Rejuran Healer with Other Fillers: Rejuran Healer can be combined with traditional fillers for areas needing both volume restoration and overall skin quality improvement.

Important Timing Note: Most doctors recommend spacing combination treatments by at least one week, performing them in the same session only when they are non-overlapping or very gentle treatments.

Important Differences: Rejuran Healer vs. Rejuran S

There is also a product called Rejuran S, and it is important to understand the difference:

Rejuran Healer contains PDRN (salmon DNA extract) and is designed primarily for skin regeneration and quality improvement. It is gentler and more focused on overall skin health.

Rejuran S contains higher concentrations of PDRN plus additional ingredients and is designed for more aggressive skin regeneration and may provide slightly more dramatic results.

Both are legitimate products from the same company, but they have different formulations and purposes. Ask your doctor which product is best suited to your specific skin concerns and goals.

Final Tips for Beginners

Important things to know before getting Rejuran Healer treatment:

Choose an Experienced Clinic: Proper injection technique is crucial for optimal results and minimal side effects. Choose a clinic with doctors experienced in administering Rejuran Healer.

Verify Product Authenticity: Rejuran Healer is a popular treatment, and counterfeit products exist. Choose a reputable clinic that can verify their product’s authenticity. Ask to see the original packaging or certification.

Have a Thorough Consultation: Before treatment, discuss your skin concerns, expectations, and desired results with the doctor. The doctor should assess whether Rejuran Healer is the best choice for your specific skin type and concerns.

Understand the Progressive Nature: Results develop gradually over weeks as skin regeneration occurs. You will not see dramatic changes immediately, but steady improvement as weeks pass.

Commit to the Recommended Course: For optimal results, commit to completing the recommended 3-4 session course rather than stopping after one session.

Take Before and After Photos: Having clear photos helps you track the improvements as they develop and appreciate the gradual skin quality improvements.

Maintain Good Skincare: Results are best when combined with a good skincare routine and sun protection. Rejuran Healer works best on skin that is well cared for.

Plan for Maintenance: After your initial course, plan for periodic maintenance sessions to sustain the improved skin quality long-term.

Be Patient: Unlike dramatic lifting or volume-adding treatments, Rejuran Healer’s benefits are about improving your skin’s actual health and quality. Results are beautiful but subtle and progressive.