Editorially Reviewed by MTK Editorial Team | September 4, 2026
Quick Answer
Rejuran is a Korean injectable medical device made with PN (polynucleotide), a purified salmon-derived DNA material. Unlike hyaluronic acid fillers, Rejuran is not primarily designed to create facial volume. PharmaResearch, the manufacturer of REJURAN®, lists the intended purpose of the original product as temporary improvement of facial wrinkles.
What is Rejuran Healer?
Rejuran Healer is the name commonly used for the original REJURAN® injectable treatment developed by South Korean manufacturer PharmaResearch. Its main component is PN, or polynucleotide.
According to PharmaResearch's official product information, REJURAN® contains PN and is intended for the temporary improvement of facial wrinkles. The manufacturer describes the material used in Rejuran as salmon-derived.
Rejuran is often grouped with treatments commonly called skin boosters in Korea, but it should not be confused with a conventional hyaluronic acid filler. Its treatment concept centers on delivering PN into the skin rather than using a gel primarily to replace volume or reshape facial contours.
If you are also comparing clinics that offer Rejuran and other skin-quality treatments, see MTK's guide to skin clinics in Korea for international patients .
Is Rejuran PN or PDRN?
The injectable REJURAN® medical device is a PN (polynucleotide) product, not a PDRN injection. PharmaResearch's official REJURAN® product information lists its composition specifically as PN.
The confusion is understandable because PharmaResearch works with both PN and PDRN technologies, and both originate from processed DNA-derived materials. However, PN and PDRN should not automatically be treated as interchangeable terms.
In simple terms:
When discussing the injectable treatment commonly called Rejuran Healer, PN (polynucleotide) is the more accurate ingredient term.
How is Rejuran different from hyaluronic acid filler?
Rejuran and hyaluronic acid fillers are both injectable treatments, but their main treatment concepts are different. Hyaluronic acid fillers are commonly used to add or restore volume and alter facial contours, while Rejuran is a PN-based product used within skin-quality and wrinkle-treatment planning.
| Feature | Rejuran | Hyaluronic Acid Filler |
|---|---|---|
| Main material | PN (polynucleotide) | Hyaluronic acid |
| Primary treatment concept | Skin-quality and wrinkle treatment | Volume and contour correction |
| Facial volume | Not the primary purpose of original REJURAN® | A major reason fillers are used |
| Typical delivery pattern | Multiple small injections across a treatment area | Strategic placement according to desired volume or contour |
Clinical research has compared PN treatments with hyaluronic acid products, but one should not be considered a universal replacement for the other. Appropriate treatment depends on the patient's concern, anatomy, skin condition and physician assessment.
What types of Rejuran are available?
PharmaResearch lists several injectable products within the REJURAN® medical-device line. They should not automatically be treated as interchangeable because their formulation, syringe volume and intended treatment areas can differ.
| Product | Composition | Official Product Information |
|---|---|---|
| REJURAN® | PN (Polynucleotide) | The original injectable REJURAN® product. PharmaResearch lists temporary improvement of facial wrinkles as its intended purpose. |
| REJURAN® i | PN (Polynucleotide) | PharmaResearch lists treatment areas including the face, particularly the eye and perioral areas, as well as the neck, décolleté and hands. |
| REJURAN® s | PN (Polynucleotide) | PharmaResearch lists temporary improvement of facial wrinkles as its intended purpose. |
| Rejuran HB Plus® | Sodium polynucleotide, sodium hyaluronate and lidocaine hydrochloride | Combines PN-related material with hyaluronic acid and lidocaine. Official Korean product information lists temporary improvement of adult crow's-feet wrinkles. |
Because individual Rejuran formulations differ, patients should confirm the exact product name and intended treatment area rather than assuming that every Rejuran injection is the same.
What happens during a Rejuran treatment?
A Rejuran appointment generally begins with a medical consultation to determine whether PN treatment is appropriate for the patient's concern and which product or treatment area is suitable.
The skin is then prepared, and clinics may use topical or local anesthesia depending on the treatment plan. Rejuran is usually delivered through multiple injections into or around the target skin area.
The exact dose, injection depth, spacing, number of injection points and technique can differ according to the product, treatment area, physician technique and individual skin condition.
How many Rejuran sessions do you need?
There is no single Rejuran treatment schedule that is appropriate for every patient. Treatment frequency depends on the indication, formulation, treatment area, skin condition and physician's plan.
Published PN studies often evaluate repeated-treatment protocols rather than a single injection session. Some research protocols have used several treatment sessions separated by a number of weeks, but these study schedules should not automatically be copied as an individualized treatment prescription.
Does Rejuran hurt?
Rejuran injections can be uncomfortable because the treatment usually involves multiple injection points. Pain tolerance, formulation and injection technique vary, and clinics may use anesthetic measures to improve treatment comfort.
Rejuran HB Plus includes lidocaine, a local anesthetic, in addition to sodium polynucleotide and hyaluronic acid.
What is the downtime after Rejuran?
Temporary injection-site reactions can occur after Rejuran treatment. These may include small raised injection marks, redness, swelling, tenderness or itching.
The appearance and duration of these reactions vary with injection technique, treatment area and individual response. Persistent, severe or unexpected symptoms should be assessed by the treating medical professional.
For broader post-treatment guidance, see MTK's Skin & Laser Aftercare Korea guide , which covers recovery considerations after injectables, skin boosters and dermatology treatments.
Before treatment
Tell your physician about medications, allergies, previous injectable treatments, current skin infections, pregnancy or breastfeeding status, and relevant medical conditions. Treatment suitability should be determined through an individual medical assessment.
Is Rejuran FDA-approved in the United States?
MTK did not identify a US FDA approval or clearance record for Rejuran in the FDA's public medical-device approval and 510(k) databases when checked on September 4, 2026. Rejuran should therefore not be described in this guide as "FDA-approved."
PharmaResearch has introduced Rejuran in multiple international markets, but international distribution, local registration and US FDA approval are different regulatory concepts. Regulatory status can change over time, so patients considering treatment outside Korea should check the current requirements in their own country.
Clinics Offering Rejuran in Korea
Rejuran is offered by aesthetic clinics across Korea, but available formulations, treatment areas and injection plans can differ by clinic. This section highlights MTK partner clinics with verified Rejuran options and can be expanded as additional clinic information is verified.
The Sinsa Clinic (더신사의원)
View Clinic & Book via MTK
The Sinsa Clinic is an aesthetic medicine clinic located in Sinsa, Gangnam, Seoul. Clinic-provided treatment materials list several Rejuran formulations alongside a broader range of skin boosters, collagen-stimulating injectables and skin-quality treatments.
May suit: Patients who want to discuss different Rejuran formulations while also comparing complementary skin-booster or skin-quality treatment options during the same consultation.
- Rejuran options: Rejuran Healer, Rejuran I, Rejuran HB and Rejuran S
- Related injectables: Juvelook Skin, Juvelook Volume, Sculptra and other clinic-listed skin boosters
- Location: Sinsa, Gangnam-gu, Seoul
- Address: 11, Dosan-daero 11-gil, Gangnam-gu, Seoul, 2nd / 5th / 6th floors
Rejuran FAQ
What is Rejuran Healer made of?
Rejuran Healer is based on PN (polynucleotide), a purified salmon-derived DNA material used in PharmaResearch's injectable REJURAN® medical device. The original REJURAN® product information lists PN as its composition.
Is Rejuran PN or PDRN?
Injectable REJURAN® is a PN (polynucleotide) product. PharmaResearch also develops PDRN-based technologies, which is one reason the two terms are sometimes confused, but they should not automatically be treated as interchangeable.
Is Rejuran the same as a filler?
Rejuran is not the same treatment concept as a conventional hyaluronic acid volumizing filler. Rejuran uses PN and is mainly used within skin-quality and wrinkle-treatment planning rather than to create facial volume.
What is the difference between Rejuran and Rejuran HB Plus?
Original REJURAN® contains PN, while Rejuran HB Plus contains sodium polynucleotide together with sodium hyaluronate and lidocaine hydrochloride. HB Plus therefore differs from the original PN-only formulation.
How many Rejuran treatments are normally needed?
The appropriate number of Rejuran treatments varies by patient and treatment goal. Published PN studies often use repeated sessions, but an individual schedule should be determined by the treating physician rather than copied from a standard package.
How long is the downtime after Rejuran?
Rejuran downtime varies, but temporary injection-site bumps, redness, swelling or tenderness can occur after treatment. Persistent, severe or unexpected symptoms should be reviewed by the treating clinic.
Is Rejuran FDA-approved?
MTK did not identify a US FDA approval or clearance record for Rejuran in the FDA's public medical-device databases when checked on September 4, 2026. Regulatory status should be checked again if treatment is being considered outside Korea.
Related Guides
Continue exploring Rejuran, dermatology treatments and medical aesthetics in Korea with these MTK guides.
Product Sources
- PharmaResearch. REJURAN® official product information. View manufacturer information
- PharmaResearch. REJURAN® i official product information. View manufacturer information
- PharmaResearch. REJURAN® s official product information. View manufacturer information
- PharmaResearch. Rejuran HB Plus® official product information. View manufacturer information
Medical References
- U.S. Food and Drug Administration. Medical-device databases. FDA database
- Clinical research comparing polynucleotide and hyaluronic acid injections for facial wrinkle treatment. PubMed Central
- Systematic review of polynucleotides in aesthetic medicine. PubMed Central
Medical Disclaimer
This guide is for general educational purposes and does not replace an in-person medical consultation, diagnosis or individualized treatment plan. Rejuran products, indications, regulatory status, injection techniques and treatment protocols may differ by country and patient. A qualified medical professional should determine whether treatment is appropriate for you.